4dqw

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Template:STRUCTURE 4dqw

Contents

Crystal Structure Analysis of PA3770

Template:ABSTRACT PUBMED 23643948

Function

[Q9HXM5_PSEAE] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]

About this Structure

4dqw is a 2 chain structure with sequence from Pseudomonas aeruginosa pao1. Full crystallographic information is available from OCA.

Reference

  • Labesse G, Alexandre T, Vaupre L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H. MgATP Regulates Allostery and Fiber Formation in IMPDHs. Structure. 2013 Jun 4;21(6):975-85. doi: 10.1016/j.str.2013.03.011. Epub 2013 May, 2. PMID:23643948 doi:10.1016/j.str.2013.03.011

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