4g4z

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Template:STRUCTURE 4g4z

Contents 1 Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii 2 Function 3 About this Structure 4 Reference

Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii

Function

[OMP38_ACIBA] Porin. Induces apoptosis in human laryngeal epithelial HEp-2 cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor).^{[1] [2]}

About this Structure

4g4z is a 8 chain structure with sequence from Acinetobacter baumannii. Full crystallographic information is available from OCA.

Reference

1. ↑ Choi CH, Lee EY, Lee YC, Park TI, Kim HJ, Hyun SH, Kim SA, Lee SK, Lee JC. Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells. Cell Microbiol. 2005 Aug;7(8):1127-38. PMID:16008580 doi:CMI538
2. ↑ Jyothisri K, Deepak V, Rajeswari MR. Purification and characterization of a major 40 kDa outer membrane protein of Acinetobacter baumannii. FEBS Lett. 1999 Jan 22;443(1):57-60. PMID:9928952