4fzb
From Proteopedia
Contents |
Structure of thymidylate synthase ThyX complexed to a new inhibitor
Template:ABSTRACT PUBMED 23155486
Function
[THYX_PBCV1] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity).
About this Structure
4fzb is a 16 chain structure with sequence from Paramecium bursaria chlorella virus 1. Full crystallographic information is available from OCA.
Reference
- Basta T, Boum Y, Briffotaux J, Becker HF, Lamarre-Jouenne I, Lambry JC, Skouloubris S, Liebl U, Graille M, van Tilbeurgh H, Myllykallio H. Mechanistic and structural basis for inhibition of thymidylate synthase ThyX. Open Biol. 2012 Oct;2(10):120120. doi: 10.1098/rsob.120120. PMID:23155486 doi:10.1098/rsob.120120
Categories: Paramecium bursaria chlorella virus 1 | Basta, T. | Becker, H F. | Boum, Y. | Briffotaux, J. | Graille, M. | Lamarre-Jouenne, I. | Lambry, J C. | Liebl, U. | Myllylkallio, H. | Skouloubris, S. | Tilbeurgh, H van. | Fad-dependent thymidylate synthase | Homotetramer | Transferase-transferase inhibitor complex
