4f14

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Template:STRUCTURE 4f14

Contents

Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2

Template:ABSTRACT PUBMED 23985323

Function

[NEBL_HUMAN] Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.[1] [XIRP2_HUMAN] Protects actin filaments from depolymerization.

About this Structure

4f14 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Eulitz S, Sauer F, Pelissier MC, Boisguerin P, Molt S, Schuld J, Orfanos Z, Kley RA, Volkmer R, Wilmanns M, Kirfel G, van der Ven PF, Furst DO. Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling. Mol Biol Cell. 2013 Oct;24(20):3215-26. doi: 10.1091/mbc.E13-04-0202. Epub 2013, Aug 28. PMID:23985323 doi:http://dx.doi.org/10.1091/mbc.E13-04-0202
  1. ↑ Li B, Zhuang L, Trueb B. Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. J Biol Chem. 2004 May 7;279(19):20401-10. Epub 2004 Mar 5. PMID:15004028 doi:10.1074/jbc.M310304200

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