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4gzd
From Proteopedia
Contents |
Crystal structure of yeast Ent2 ENTH domain triple mutant N112D,S114E, E118Q
Template:ABSTRACT PUBMED 23553749
Function
[ENT2_YEAST] Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin.[1]
About this Structure
4gzd is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.
Reference
- Costakes GT, Sen A, Aguilar RC, Stauffacher CV. Crystallographic analysis of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype. Protein Sci. 2013 Mar 30. doi: 10.1002/pro.2259. PMID:23553749 doi:10.1002/pro.2259
- ↑ Wendland B, Steece KE, Emr SD. Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J. 1999 Aug 16;18(16):4383-93. PMID:10449404 doi:10.1093/emboj/18.16.4383
