4ga3
From Proteopedia
Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260
Template:ABSTRACT PUBMED 23610597
Function
[FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
About this Structure
4ga3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
