4i63

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4i63

Contents 1 Crystal Structure of E-R ClpX Hexamer 2 Function 3 About this Structure 4 Reference

Crystal Structure of E-R ClpX Hexamer

Template:ABSTRACT PUBMED 23622246

Function

[CLPX_ECOLI] ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP.[HAMAP-Rule:MF_00175]

About this Structure

4i63 is a 6 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

• Stinson BM, Nager AR, Glynn SE, Schmitz KR, Baker TA, Sauer RT. Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell. 2013 Apr 25;153(3):628-39. doi: 10.1016/j.cell.2013.03.029. PMID:23622246 doi:10.1016/j.cell.2013.03.029