4i8v

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Template:STRUCTURE 4i8v

Contents

Human Cytochrome P450 1A1 in complex with alpha-naphthoflavone

Template:ABSTRACT PUBMED 23508959

Function

[CP1A1_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

About this Structure

4i8v is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Walsh AA, Szklarz GD, Scott EE. Human Cytochrome P450 1A1 Structure and Utility In Understanding Drug and Xenobiotic Metabolism. J Biol Chem. 2013 Mar 18. PMID:23508959 doi:10.1074/jbc.M113.452953

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OCA

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