4j7q

From Proteopedia

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Template:STRUCTURE 4j7q

Contents 1 Crystal structure of Saccharomyces cerevisiae Sfh3 complexed with phosphatidylinositol 2 Function 3 About this Structure 4 Reference

Crystal structure of Saccharomyces cerevisiae Sfh3 complexed with phosphatidylinositol

Template:ABSTRACT PUBMED 23603387

Function

[PDR16_YEAST] Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover.^{[1] [2]}

About this Structure

4j7q is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

• Yang H, Tong J, Leonard TA, Im YJ. Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles. FEBS Lett. 2013 Jun 5;587(11):1610-6. doi: 10.1016/j.febslet.2013.04.009. Epub, 2013 Apr 18. PMID:23603387 doi:10.1016/j.febslet.2013.04.009

1. ↑ van den Hazel HB, Pichler H, do Valle Matta MA, Leitner E, Goffeau A, Daum G. PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J Biol Chem. 1999 Jan 22;274(4):1934-41. PMID:9890948
2. ↑ Li X, Routt SM, Xie Z, Cui X, Fang M, Kearns MA, Bard M, Kirsch DR, Bankaitis VA. Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell. 2000 Jun;11(6):1989-2005. PMID:10848624