4hj0

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Template:STRUCTURE 4hj0

Contents

Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution

Template:ABSTRACT PUBMED 23689510

Function

[GIPR_HUMAN] This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

About this Structure

4hj0 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ravn P, Madhurantakam C, Kunze S, Matthews E, Priest C, O'brien S, Collinson A, Papworth M, Fritsch-Fredin M, Jermutus L, Benthem L, Gruetter M, Jackson RH. Structural and Pharmacological Characterisation of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-Dependent Insulinotropic Polypeptide Receptor. J Biol Chem. 2013 May 20. PMID:23689510 doi:10.1074/jbc.M112.426288

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