4jgw

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Template:STRUCTURE 4jgw

Contents

The conformation of a docking site for SH3 domains is pre-selected in the Guanine Nucleotide Exchange Factor Rlf

Template:ABSTRACT PUBMED 23891840

Function

[RGL2_MOUSE] Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro.

About this Structure

4jgw is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Popovic M, Jakobi AJ, Rensen-de Leeuw M, Rehmann H. The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation. J Struct Biol. 2013 Sep;183(3):312-9. doi: 10.1016/j.jsb.2013.07.009. Epub 2013, Jul 24. PMID:23891840 doi:10.1016/j.jsb.2013.07.009

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