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4isq
From Proteopedia
Contents |
Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I
Template:ABSTRACT PUBMED 23932591
Function
[SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
About this Structure
4isq is a 6 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
Reference
- Berntsson RP, Peng L, Svensson LM, Dong M, Stenmark P. Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II. Structure. 2013 Sep 3;21(9):1602-11. doi: 10.1016/j.str.2013.06.026. Epub 2013, Aug 8. PMID:23932591 doi:http://dx.doi.org/10.1016/j.str.2013.06.026
