4i06
From Proteopedia
Crystal structure of human Arginase-2 complexed with inhibitor 14
Template:ABSTRACT PUBMED 23472952
Function
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this Structure
4i06 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Arginase | Homo sapiens | Andreoli, M. | Beckett ,P. | Conway, B. | Cousido-Siah, A. | Golebiowski, A. | Ji, M. | Mahboubi, K. | Mitschler, A. | Podjarny, A. | Ruiz, F X. | Schroeter, H. | Sheeler, R. | Whitehouse, D L. | Zandt, M C.Van. | Zhang, M. | Alpha/beta fold | Arginine metabolism | Hydrolase | Manganese | Metalloenzyme | Mitochondrion
