4j4a

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Template:STRUCTURE 4j4a

Contents

Crystal Structure of Engineered Trimeric Cortexillin-1 Coiled-Coil Variant

Template:ABSTRACT PUBMED 23691037

Function

[CTXA_DICDI] Acting-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1.[1]

About this Structure

4j4a is a 12 chain structure with sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

  • Bjelic S, Wieser M, Frey D, Stirnimann CU, Chance MR, Jaussi R, Steinmetz MO, Kammerer RA. Structural basis for the oligomerization-state switch from a dimer to a trimer of an engineered cortexillin-1 coiled-coil variant. PLoS One. 2013 May 14;8(5):e63370. doi: 10.1371/journal.pone.0063370. Print 2013. PMID:23691037 doi:10.1371/journal.pone.0063370
  1. ↑ Jeon TJ, Lee DJ, Lee S, Weeks G, Firtel RA. Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells. J Cell Biol. 2007 Dec 3;179(5):833-43. Epub 2007 Nov 26. PMID:18039932 doi:jcb.200705068

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