4hyt

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Template:STRUCTURE 4hyt

Contents 1 Na,K-ATPase in the E2P state with bound ouabain and Mg2+ in the cation-binding site 2 Function 3 About this Structure 4 Reference

Na,K-ATPase in the E2P state with bound ouabain and Mg2+ in the cation-binding site

Template:ABSTRACT PUBMED 23776223

Function

[AT1A1_PIG] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [AT1B1_PIG] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

About this Structure

4hyt is a 6 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

• Laursen M, Yatime L, Nissen P, Fedosova NU. Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10958-63. doi:, 10.1073/pnas.1222308110. Epub 2013 Jun 17. PMID:23776223 doi:10.1073/pnas.1222308110