4j6s

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Template:STRUCTURE 4j6s

Contents

14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43)

Template:ABSTRACT PUBMED 24055376

Function

[1433G_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.[1]

About this Structure

4j6s is a 8 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Skjevik AA, Mileni M, Baumann A, Halskau O, Teigen K, Stevens RC, Martinez A. The N-Terminal Sequence of Tyrosine Hydroxylase Is a Conformationally Versatile Motif That Binds 14-3-3 Proteins and Membranes. J Mol Biol. 2013 Sep 17. pii: S0022-2836(13)00583-4. doi:, 10.1016/j.jmb.2013.09.012. PMID:24055376 doi:http://dx.doi.org/10.1016/j.jmb.2013.09.012
  1. ↑ Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 Mar 22;25(6):1207-18. Epub 2006 Mar 2. PMID:16511572 doi:10.1038/sj.emboj.7601010

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