4hq0

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Template:STRUCTURE 4hq0

Contents

Crystal Structure of mutant form of Caspase-7

Template:ABSTRACT PUBMED 23897474

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4hq0 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kang HJ, Lee YM, Bae KH, Kim SJ, Chung SJ. Structural asymmetry of procaspase-7 bound to a specific inhibitor. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1514-21. doi:, 10.1107/S0907444913010196. Epub 2013 Jul 18. PMID:23897474 doi:10.1107/S0907444913010196

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OCA

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