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4knz

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Revision as of 13:19, 19 June 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 4knz

Contents

Thymidylate synthase ternary complex with dUMP AND CB3717

Template:ABSTRACT PUBMED 23611499

Function

[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.

About this Structure

4knz is a 2 chain structure with sequence from Escherichia coli k-12. This structure supersedes the now removed PDB entries and 2g8o. Full crystallographic information is available from OCA.

Reference

  • Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A. Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc. 2013 Apr 23. PMID:23611499 doi:10.1021/ja400761x

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OCA

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