This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ldr
From Proteopedia
Contents |
Structure of the S283Y mutant of MRDI
Template:ABSTRACT PUBMED 23859498
Function
[MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.[1]
About this Structure
4ldr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC. Structure of MRDI Explains its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion. Biochemistry. 2013 Jul 16. PMID:23859498 doi:10.1021/bi400556e
- ↑ Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009 Oct;8(10):2308-20. doi: 10.1074/mcp.M900178-MCP200., Epub 2009 Jul 20. PMID:19620624 doi:10.1074/mcp.M900178-MCP200
