4mcb

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4mcb

Contents 1 H.influenzae TrmD in complex with N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE 2 Function 3 About this Structure 4 Reference

H.influenzae TrmD in complex with N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE

Template:ABSTRACT PUBMED 23981144

Function

[TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]

About this Structure

4mcb is a 2 chain structure with sequence from Haemophilus influenzae rd kw20. Full crystallographic information is available from OCA.

Reference

• Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET. Selective Inhibitors of Bacterial t-RNA-(NG37) Methyltransferase (TrmD) that Demonstrate Novel Ordering of the Lid Domain. J Med Chem. 2013 Aug 27. PMID:23981144 doi:10.1021/jm400718n