4m5d

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Template:STRUCTURE 4m5d

Contents

Crystal structure of the Utp22 and Rrp7 complex from Saccharomyces cerevisiae

Template:ABSTRACT PUBMED 24130456

Function

[UTP22_YEAST] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[1] [RRP7_YEAST] Plays an important role in the synthesis of 18S rRNA but is not required for the 5.8S and 25S pathway. Is necessary for the cleavage at site A2. Is required for efficient association of RPS27 with the pre-ribosomal particle.

About this Structure

4m5d is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  • Lin J, Lu J, Feng Y, Sun M, Ye K. An RNA-Binding Complex Involved in Ribosome Biogenesis Contains a Protein with Homology to tRNA CCA-Adding Enzyme. PLoS Biol. 2013 Oct;11(10):e1001669. doi: 10.1371/journal.pbio.1001669. Epub 2013, Oct 1. PMID:24130456 doi:http://dx.doi.org/10.1371/journal.pbio.1001669
  1. ↑ Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ. The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell. 2004 Dec;3(6):1619-26. PMID:15590835 doi:http://dx.doi.org/10.1128/EC.3.6.1619-1626.2004

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