4klb

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Template:STRUCTURE 4klb

Contents

Crystal Structure of Cruzain in complex with the non-covalent inhibitor Nequimed176

Template:ABSTRACT PUBMED 23991231

Function

[CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.

About this Structure

4klb is a 5 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

  • Wiggers HJ, Rocha JR, Fernandes WB, Sesti-Costa R, Carneiro ZA, Cheleski J, da Silva AB, Juliano L, Cezari MH, Silva JS, McKerrow JH, Montanari CA. Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay. PLoS Negl Trop Dis. 2013 Aug 22;7(8):e2370. doi: 10.1371/journal.pntd.0002370. PMID:23991231 doi:10.1371/journal.pntd.0002370

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