4jr2

From Proteopedia

Revision as of 15:37, 19 June 2013 by OCA (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 4jr2

Contents

Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK

Template:ABSTRACT PUBMED 23650375

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4jr2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Thomsen ND, Koerber JT, Wells JA. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8477-82. doi:, 10.1073/pnas.1306759110. Epub 2013 May 6. PMID:23650375 doi:10.1073/pnas.1306759110

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jr2"
Personal tools