4k17

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Template:STRUCTURE 4k17

Contents

Crystal Structure of mouse CARMIL residues 1-668

Template:ABSTRACT PUBMED 24071777

Function

[LR16A_MOUSE] Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization.[1]

About this Structure

4k17 is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Zwolak A, Yang C, Feeser EA, Michael Ostap E, Svitkina T, Dominguez R. CARMIL leading edge localization depends on a non-canonical PH domain and dimerization. Nat Commun. 2013 Sep 27;4:2523. doi: 10.1038/ncomms3523. PMID:24071777 doi:http://dx.doi.org/10.1038/ncomms3523
  1. ↑ Yang C, Pring M, Wear MA, Huang M, Cooper JA, Svitkina TM, Zigmond SH. Mammalian CARMIL inhibits actin filament capping by capping protein. Dev Cell. 2005 Aug;9(2):209-21. PMID:16054028 doi:http://dx.doi.org/10.1016/j.devcel.2005.06.008

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