4lfq

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Template:STRUCTURE 4lfq

Contents

High resolution x-ray crystal structure of L-ShK toxin

Template:ABSTRACT PUBMED 23919482

Function

[TXSHK_STOHE] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.[1]

About this Structure

4lfq is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Dang B, Kubota T, Mandal K, Bezanilla F, Kent SB. Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography. J Am Chem Soc. 2013 Aug 6. PMID:23919482 doi:10.1021/ja4046795
  1. ↑ Castaneda O, Sotolongo V, Amor AM, Stocklin R, Anderson AJ, Harvey AL, Engstrom A, Wernstedt C, Karlsson E. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33(5):603-13. PMID:7660365

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