1sij
From Proteopedia
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Crystal structure of the Aldehyde Dehydrogenase (a.k.a. AOR or MOP) of Desulfovibrio gigas covalently bound to [AsO3]-
Overview
X-ray crystallography has been used to determine the structure of arsenite-inhibited aldehyde dehydrogenase from Desulfovibrio gigas, a member of the xanthine oxidase family of mononuclear molybdenum enzymes. The structure shows an AsO3 moiety bound to the molybdenum atom of the active site through one of the oxygen atoms. A reduced sample of arsenite-inhibited aldehyde dehydrogenase has a Mo(V) signal that shows anisotropic hyperfine and quadrupole coupling to one arsenic atom. This signal has a strong resemblance with a previously reported signal for arsenite-inhibited xanthine oxidase.
About this Structure
1SIJ is a Single protein structure of sequence from Desulfovibrio gigas with , , , and as ligands. Active as Aldehyde oxidase, with EC number 1.2.3.1 Full crystallographic information is available from OCA.
Reference
X-ray crystal structure and EPR spectra of "arsenite-inhibited" Desulfovibriogigas aldehyde dehydrogenase: a member of the xanthine oxidase family., Boer DR, Thapper A, Brondino CD, Romao MJ, Moura JJ, J Am Chem Soc. 2004 Jul 21;126(28):8614-5. PMID:15250689
Page seeded by OCA on Thu Feb 21 15:01:51 2008
