3ix0
From Proteopedia
Contents |
Crystal structure of human seminal plasma protein PSP94
Template:ABSTRACT PUBMED 20184897
Disease
[MSMB_HUMAN] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:611928]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
About this Structure
3ix0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kumar A, Jagtap DD, Mahale SD, Kumar M. Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer. J Mol Biol. 2010 Apr 9;397(4):947-56. Epub 2010 Feb 23. PMID:20184897 doi:10.1016/j.jmb.2010.02.035
