4f3v

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Template:STRUCTURE 4f3v

Contents 1 Crystal structure of N-terminal domain of EccA1 ATPase from ESX-1 secretion system of Mycobacterium tuberculosis 2 Function 3 About this Structure 4 Reference

Crystal structure of N-terminal domain of EccA1 ATPase from ESX-1 secretion system of Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 23818233

Function

[ECCA1_MYCTU] Probably part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). Shows ATPase activity. Could provide energy for export of ESX-1 substrates.^{[1] [2]}

About this Structure

4f3v is a 2 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA.

Reference

• Wagner JM, Evans TJ, Korotkov KV. Crystal structure of the N-terminal domain of EccA ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis. Proteins. 2013 Jul 2. doi: 10.1002/prot.24351. PMID:23818233 doi:10.1002/prot.24351

1. ↑ Luthra A, Mahmood A, Arora A, Ramachandran R. Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis. J Biol Chem. 2008 Dec 26;283(52):36532-41. doi: 10.1074/jbc.M807144200. Epub 2008, Oct 30. PMID:18974091 doi:10.1074/jbc.M807144200
2. ↑ Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, Demangel C, Hinds J, Neyrolles O, Butcher PD, Leclerc C, Cole ST, Brosch R. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun. 2006 Jan;74(1):88-98. PMID:16368961 doi:10.1128/IAI.74.1.88-98.2006