4c8e

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Template:STRUCTURE 4c8e

Contents

IspF (Burkholderia cenocepacia) 2CMP complex

Template:ABSTRACT PUBMED 24410837

Function

[ISPF_BURCJ] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).

About this Structure

4c8e is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • O Rourke PE, Kalinowska-T U Cik J, Fyfe PK, Dawson A, Hunter WN. Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment. BMC Struct Biol. 2014 Jan 10;14(1):1. PMID:24410837 doi:http://dx.doi.org/10.1186/1472-6807-14-1

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