4m9f
From Proteopedia
Contents |
Dengue virus NS2B-NS3 protease A125C variant at pH 8.5
Template:ABSTRACT PUBMED 24164286
Function
[Q91H74_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
About this Structure
4m9f is a 1 chain structure with sequence from Dengue virus 2. Full crystallographic information is available from OCA.
Reference
- Yildiz M, Ghosh S, Bell JA, Sherman W, Hardy JA. Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus. ACS Chem Biol. 2013 Oct 28. PMID:24164286 doi:http://dx.doi.org/10.1021/cb400612h
