3zif
From Proteopedia
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Contents |
Cryo-EM structures of two intermediates provide insight into adenovirus assembly and disassembly
Template:ABSTRACT PUBMED 24503080
Function
[CAPSH_ADEB3] Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus (By similarity).
About this Structure
3zif is a 18 chain structure with sequence from Bovine adenovirus 3. Full crystallographic information is available from OCA.
Reference
- Cheng L, Huang X, Li X, Xiong W, Sun W, Yang C, Zhang K, Wang Y, Liu H, Huang X, Ji G, Sun F, Zheng C, Zhu P. Cryo-EM structures of two bovine adenovirus type 3 intermediates. Virology. 2014 Feb;450-451:174-81. doi: 10.1016/j.virol.2013.12.012. Epub 2014, Jan 3. PMID:24503080 doi:http://dx.doi.org/10.1016/j.virol.2013.12.012
