4k3m

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Template:STRUCTURE 4k3m

Contents

E.coli sliding clamp in complex with AcALDLF peptide

Template:ABSTRACT PUBMED 24090409

Function

[DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.

About this Structure

4k3m is a 3 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

Reference

  • Yin Z, Kelso MJ, Beck JL, Oakley AJ. Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp. J Med Chem. 2013 Nov 14;56(21):8665-73. doi: 10.1021/jm401118f. Epub 2013 Oct 22. PMID:24090409 doi:http://dx.doi.org/10.1021/jm401118f

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