3b0o

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Template:STRUCTURE 3b0o

Contents

Crystal structure of alpha-lactalbumin

Template:ABSTRACT PUBMED 23155056

Function

[LALBA_HUMAN] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

About this Structure

3b0o is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Makabe K, Nakamura T, Kuwajima K. Structural insights into the stability perturbations induced by N-terminal variation in human and goat alpha-lactalbumin. Protein Eng Des Sel. 2013 Feb;26(2):165-70. doi: 10.1093/protein/gzs093. Epub, 2012 Nov 14. PMID:23155056 doi:http://dx.doi.org/10.1093/protein/gzs093

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