4m7h

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Template:STRUCTURE 4m7h

Contents 1 Crystal structure of tetrameric fibrinogen-like recognition domain of FIBCD1 2 Function 3 About this Structure 4 Reference

Crystal structure of tetrameric fibrinogen-like recognition domain of FIBCD1

Template:ABSTRACT PUBMED 24293368

Function

[FBCD1_HUMAN] Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.^{[1] [2]}

About this Structure

4m7h is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

• Shrive AK, Moeller JB, Burns I, Paterson JM, Shaw AJ, Schlosser A, Sorensen GL, Greenhough TJ, Holmskov U. Crystal structure of the tetrameric fibrinogen-like recognition domain of Fibrinogen C domain containing 1 (FIBCD1). J Biol Chem. 2013 Dec 19. PMID:24293368 doi:http://dx.doi.org/10.1074/jbc.M113.520577

1. ↑ Schlosser A, Thomsen T, Moeller JB, Nielsen O, Tornoe I, Mollenhauer J, Moestrup SK, Holmskov U. Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. J Immunol. 2009 Sep 15;183(6):3800-9. doi: 10.4049/jimmunol.0901526. Epub 2009, Aug 26. PMID:19710473 doi:http://dx.doi.org/10.4049/jimmunol.0901526
2. ↑ Thomsen T, Moeller JB, Schlosser A, Sorensen GL, Moestrup SK, Palaniyar N, Wallis R, Mollenhauer J, Holmskov U. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. J Biol Chem. 2010 Jan 8;285(2):1229-38. doi: 10.1074/jbc.M109.061523. Epub 2009, Nov 5. PMID:19892701 doi:http://dx.doi.org/10.1074/jbc.M109.061523