4n5q

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Template:STRUCTURE 4n5q

Contents

Crystal structure of the N-terminal ankyrin repeat domain of TRPV3

Template:ABSTRACT PUBMED 24248473

Function

[TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).

About this Structure

4n5q is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Shi DJ, Ye S, Cao X, Zhang R, Wang K. Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of finger 3 loop critical for channel function. Protein Cell. 2013 Dec;4(12):942-50. doi: 10.1007/s13238-013-3091-0. Epub 2013, Nov 18. PMID:24248473 doi:http://dx.doi.org/10.1007/s13238-013-3091-0

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