4ia0

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Template:STRUCTURE 4ia0

Contents

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

Template:ABSTRACT PUBMED 23867165

Function

[PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.

About this Structure

4ia0 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. , Epub 2013 Jun 29. PMID:23867165 doi:http://dx.doi.org/10.1016/j.bmcl.2013.06.062

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