4n78

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Template:STRUCTURE 4n78

Contents

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

Template:ABSTRACT PUBMED 24439376

Disease

[CYFP1_HUMAN] Angelman syndrome.

Function

[BRK1_HUMAN] Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.[1] [CYFP1_HUMAN] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.[2] [3] [4] [5] [WASF1_HUMAN] Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. [NCKP1_HUMAN] Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.

About this Structure

4n78 is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK. The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton. Cell. 2014 Jan 16;156(1-2):195-207. doi: 10.1016/j.cell.2013.11.048. PMID:24439376 doi:http://dx.doi.org/10.1016/j.cell.2013.11.048
  1. ↑ Derivery E, Fink J, Martin D, Houdusse A, Piel M, Stradal TE, Louvard D, Gautreau A. Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One. 2008 Jun 18;3(6):e2462. doi: 10.1371/journal.pone.0002462. PMID:18560548 doi:http://dx.doi.org/10.1371/journal.pone.0002462
  2. ↑ Kobayashi K, Kuroda S, Fukata M, Nakamura T, Nagase T, Nomura N, Matsuura Y, Yoshida-Kubomura N, Iwamatsu A, Kaibuchi K. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J Biol Chem. 1998 Jan 2;273(1):291-5. PMID:9417078
  3. ↑ Kawano Y, Yoshimura T, Tsuboi D, Kawabata S, Kaneko-Kawano T, Shirataki H, Takenawa T, Kaibuchi K. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol. 2005 Nov;25(22):9920-35. PMID:16260607 doi:http://dx.doi.org/25/22/9920
  4. ↑ Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell. 2009 Jun 12;137(6):1047-61. doi: 10.1016/j.cell.2009.04.013. PMID:19524508 doi:http://dx.doi.org/10.1016/j.cell.2009.04.013
  5. ↑ Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK. Structure and control of the actin regulatory WAVE complex. Nature. 2010 Nov 25;468(7323):533-8. PMID:21107423 doi:10.1038/nature09623

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