4mjv
From Proteopedia
Contents |
Influenza Neuraminidase in complex with a novel antiviral compound
Template:ABSTRACT PUBMED 24339250
Function
[NRAM_I63A3] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
About this Structure
4mjv is a 1 chain structure with sequence from Influenza a virus. Full crystallographic information is available from OCA.
Reference
- Mohan S, Kerry PS, Bance N, Niikura M, Pinto BM. Serendipitous Discovery of a Potent Influenza Virus A Neuraminidase Inhibitor. Angew Chem Int Ed Engl. 2013 Dec 11. doi: 10.1002/anie.201308142. PMID:24339250 doi:http://dx.doi.org/10.1002/anie.201308142
