4nam

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Template:STRUCTURE 4nam

Contents

1.7A structure of 5-Fluoro Tryptophan Labeled Protective Antigen (W206Y)

Template:ABSTRACT PUBMED 24387629

Function

[PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.

About this Structure

4nam is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Chadegani F, Lovell S, Mullangi V, Miyagi M, Battaile KP, Bann JG. F Nuclear Magnetic Resonance and Crystallographic Studies of 5-Fluorotryptophan-Labeled Anthrax Protective Antigen and Effects of the Receptor on Stability. Biochemistry. 2014 Jan 15. PMID:24387629 doi:http://dx.doi.org/10.1021/bi401405s

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