2m5i

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Template:STRUCTURE 2m5i

Contents

NMR structures of human apoptotic protein tBid in LPPG micelle

Template:ABSTRACT PUBMED 24158446

Function

[BID_HUMAN] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.[1]

About this Structure

2m5i is a 1 chain structure with sequence from Human. Full experimental information is available from OCA.

Reference

  1. ↑ Renshaw SA, Dempsey CE, Barnes FA, Bagstaff SM, Dower SK, Bingle CD, Whyte MK. Three novel Bid proteins generated by alternative splicing of the human Bid gene. J Biol Chem. 2004 Jan 23;279(4):2846-55. Epub 2003 Oct 28. PMID:14583606 doi:http://dx.doi.org/10.1074/jbc.M309769200

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