4kth
From Proteopedia
Contents |
Structure of A/Hubei/1/2010 H5 HA
Template:ABSTRACT PUBMED 24086467
Function
[G2U0T8_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013828_004_327643]
About this Structure
4kth is a 6 chain structure. Full crystallographic information is available from OCA.
Reference
- Shore DA, Yang H, Balish AL, Shepard SS, Carney PJ, Chang JC, Davis CT, Donis RO, Villanueva JM, Klimov AI, Stevens J. Structural and Antigenic Variation among Diverse Clade 2 H5N1 Viruses. PLoS One. 2013 Sep 27;8(9):e75209. doi: 10.1371/journal.pone.0075209. PMID:24086467 doi:http://dx.doi.org/10.1371/journal.pone.0075209
