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4chc

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Template:STRUCTURE 4chc

Contents

Crystal structure of the N-terminal domain of the PA subunit of Thogoto virus polymerase (form 2)

Template:ABSTRACT PUBMED 24454773

Function

[PA_THOGV] Initiates transcription by a unique cap-stealing mechanism that involves the cleavage of only the m(7)GpppAm structure from cellular hnRNAs.

About this Structure

4chc is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Guilligay D, Kadlec J, Crepin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S. Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains. PLoS One. 2014 Jan 15;9(1):e84973. doi: 10.1371/journal.pone.0084973. eCollection, 2014 Jan 15. PMID:24454773 doi:http://dx.doi.org/10.1371/journal.pone.0084973

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OCA

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