1agg

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Template:STRUCTURE 1agg

Contents

THE SOLUTION STRUCTURE OF OMEGA-AGA-IVB, A P-TYPE CALCIUM CHANNEL ANTAGONIST FROM THE VENOM OF AGELENOPSIS APERTA

Template:ABSTRACT PUBMED 7703698

Function

[TOG4B_AGEAP] Antagonist of voltage-gated Cav2.1/CACNA1A (P-type) calcium channels. Paralyzes insect by blocking neuromuscular transmission.[1]

About this Structure

1agg is a 1 chain structure with sequence from Agelenopsis aperta. Full experimental information is available from OCA.

Reference

  • Reily MD, Thanabal V, Adams ME. The solution structure of omega-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta. J Biomol NMR. 1995 Feb;5(2):122-32. PMID:7703698
  1. ↑ Adams ME, Mintz IM, Reily MD, Thanabal V, Bean BP. Structure and properties of omega-agatoxin IVB, a new antagonist of P-type calcium channels. Mol Pharmacol. 1993 Oct;44(4):681-8. PMID:8232218

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