4mz2

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Template:STRUCTURE 4mz2

Contents

Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain

Template:ABSTRACT PUBMED 24297919

Disease

[SCN4B_HUMAN] Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

[SCN4B_HUMAN] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity).

About this Structure

4mz2 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Gilchrist J, Das S, Van Petegem F, Bosmans F. Crystallographic insights into sodium-channel modulation by the beta4 subunit. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E5016-24. doi:, 10.1073/pnas.1314557110. Epub 2013 Dec 2. PMID:24297919 doi:http://dx.doi.org/10.1073/pnas.1314557110

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