3k82
From Proteopedia
Contents |
Crystal Structure of the third PDZ domain of PSD-95
Template:ABSTRACT PUBMED 20227506
Function
[DLG4_HUMAN] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
About this Structure
3k82 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Camara-Artigas A, Murciano-Calles J, Gavira JA, Cobos ES, Martinez JC. Novel conformational aspects of the third PDZ domain of the neuronal post-synaptic density-95 protein revealed from two 1.4A X-ray structures. J Struct Biol. 2010 Jun;170(3):565-9. Epub 2010 Mar 19. PMID:20227506 doi:10.1016/j.jsb.2010.03.005
