4c77

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Template:STRUCTURE 4c77

Contents

Phenylacetone monooxygenase: oxidised R337K mutant in complex with APADP

Template:ABSTRACT PUBMED 24443704

Function

[PAMO_THEFY] Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl acetate. Can also oxidize other aromatic ketones (benzylacetone, alpha-methylphenylacetone and 4-hydroxyacetophenone), some aliphatic ketones (dodecan-2-one and bicyclohept-2-en-6-one) and sulfides (e.g. methyl 4-tolylsulfide).

About this Structure

4c77 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Martinoli C, Dudek HM, Orru R, Edmondson DE, Fraaije MW, Mattevi A. Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction. ACS Catal. 2013;3(12):3058-3062. PMID:24443704 doi:http://dx.doi.org/10.1021/cs400837z

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