1akp

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Template:STRUCTURE 1akp

Contents

SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN

Template:ABSTRACT PUBMED 7918358

Function

[KEDA_ACTSL] Binds non-covalently to an enediyne chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore cleaves duplex DNA site-specifically in a single-stranded manner. The apoprotein cleaves proteins selectively, in particular highly basic histones, with H1 proteins being cleaved the more readily.

About this Structure

1akp is a 1 chain structure with sequence from Actinomycete atcc 53650. Full experimental information is available from OCA.

Reference

  • Constantine KL, Colson KL, Wittekind M, Friedrichs MS, Zein N, Tuttle J, Langley DR, Leet JE, Schroeder DR, Lam KS, et al.. Sequential 1H, 13C, and 15N NMR assignments and solution conformation of apokedarcidin. Biochemistry. 1994 Sep 27;33(38):11438-52. PMID:7918358

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