The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds.
A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA.,Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH. A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA. Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126
