Publication Abstract from PubMed
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.
Structure and mechanism of DNA topoisomerase II.,Berger JM, Gamblin SJ, Harrison SC, Wang JC Nature. 1996 Jan 18;379(6562):225-32. PMID:8538787[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
