1upi
From Proteopedia
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MYCOBACTERIUM TUBERCULOSIS RMLC EPIMERASE (RV3465)
Overview
The Mycobacterium tuberculosis rmlC gene encodes dTDP-4-keto-6-deoxyglucose epimerase, the third enzyme in the M. tuberculosis dTDP-L-rhamnose pathway which is essential for mycobacterial cell-wall synthesis. Because it is structurally unique, highly substrate-specific and does not require a cofactor, RmlC is considered to be the most promising drug target in the pathway, and the M. tuberculosis rmlC gene was selected in the initial round of TB Structural Genomics Consortium targets for structure determination. The 1.7 A native structure determined by the consortium facilities is reported and implications for in silico screening of ligands for structure-guided drug design are discussed.
About this Structure
1UPI is a Single protein structure of sequence from Mycobacterium tuberculosis. Active as dTDP-4-dehydrorhamnose 3,5-epimerase, with EC number 5.1.3.13 Full crystallographic information is available from OCA.
Reference
Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway., Kantardjieff KA, Kim CY, Naranjo C, Waldo GS, Lekin T, Segelke BW, Zemla A, Park MS, Terwilliger TC, Rupp B, Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):895-902. Epub 2004, Apr 21. PMID:15103135
Page seeded by OCA on Thu Feb 21 15:27:01 2008
Categories: Mycobacterium tuberculosis | Single protein | DTDP-4-dehydrorhamnose 3,5-epimerase | Kantardjieff, K A. | Kim, C Y. | Lekin, T. | Naranjo, C. | Rupp, B. | Segelke, B W. | TBSGC, TB Structural Genomics Consortium. | Terwilliger, T. | Waldo, G S. | Zemla, A. | Epimerase | Protein structure initiative | Psi | Rhamnose pathway | Tb | Tb structural genomics consortium | Tbsgc
